Parenteral nutrition with fish oil-based lipid emulsion reduces the risk of cholestasis in preterm infants

Objective Preterm infants receive long-term parenteral nutrition (PN) for gastrointestinal immaturity. This study aimed to determine if mixed lipid emulsions containing fish oil decrease the incidence of PN-associated cholestasis by reducing oxidative stress and providing an anti-inflammatory effect. Methods retrospective cohort enrolled 399 very low birth weight premature (gestational age ≤32 weeks) between January 2009 November 2017 at a single neonatal intensive care unit. received total PN with either emulsion including (SMOFlipid®, n = 195) or soybean oil-based (Lipovenoes®, 204) least 7 days. We compared outcomes cholestasis, comorbidities, mortality groups. Results The was significantly lower in SMOFlipid group than Lipovenoes group. duration full feeding days shorter Relevant complications, such as severe retinopathy prematurity bronchopulmonary dysplasia, were also reduced Conclusion In infants, is associated emulsions.